Plasmacytoma in Membranoproliferative Glomerulonephritis: A Case Report

Abstract

Multiple myeloma is a prevalent disease, whereas bone 
plasmacytoma is a localized neoplasm of monoclonal plasma 
cells, constituting a distinct plasma cell disorder that falls 
between monoclonal gammopathy of undetermined significance 
(MGUS) and multiple myeloma (MM). We present a 63-year
old woman who exhibited proteinuria and acute kidney injury 
(AKI), subsequently diagnosed with membranoproliferative 
glomerulonephritis (MPGN) of unknown etiology. One year 
later, the patient developed a lytic bone lesion and diagnosed 
as having a solitary bone plasmacytoma. MPGN may be caused 
by immunological complexes or associated with monoclonal 
gammopathy; therefore, it is essential to assess individuals 
with MPGN to identify any typical or atypical etiologies of the 
condition.